Senior Research Investigator, (Biologics Pharmacology), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.  Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.  About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.   Your Impact We’re seeking a Senior Research Investigator specialising in biologics drug development to contribute to the pharmacology and translational biology strategy of our novel large molecule therapeutics, harnessing the transformative power of our cutting-edge AI drug design engine. This role requires a unique blend of scientific expertise and the intellectual curiosity to explore uncharted territory in therapeutic design. Within the Biologics Design and Research team, you will play a pivotal role in our drug discovery projects, working with key internal and external stakeholders to drive the pharmacology strategy of complex projects in early discovery through to candidate selection and, ultimately, advancing candidates towards the clinic. This is an extraordinary opportunity to collaborate closely with Isomorphic Labs’ world-leading AI, ML, and drug discovery experts, developing imaginative new approaches, based on generative AI, to design and optimise protein-based therapeutics. What You Will Do Translational Biology Strategy: Design, execute, and oversee comprehensive pharmacology plans for our large molecule therapeutics.  In Vivo & In Vitro Evaluation: Lead the design and execution of in vivo efficacy and complex in vitro functional assays to ensure high-quality data generation. Drive Project Milestones: Act as the Biology Lead for assigned projects, coordinating complex internal workflows and external CROs to efficiently progress candidates toward critical go/no-go decisions and program milestones. New Target Identification: Collaborate with computational biology and design teams to identify, evaluate, and bring new biologics projects into the portfolio, assessing biological feasibility and therapeutic potential. Collaborative Platform Building: Partner closely with interdisciplinary teams (ML, Biology, CompBio) to help build our generative AI platform, ensuring the pharmacology data you generate is effectively fed back into design loops, while collaborating to deploy these cutting-edge tools to discover novel therapeutic strategies. Essential Skills and Qualifications: PhD in Immunology, Cancer Biology, Molecular Biology, Biochemistry, Pharmacology or a related scientific discipline. 5+ years’ professional experience in an industry role within a biotech or pharma setting. A strong scientific expertise in, and in-depth understanding of, disease models and their use in biologics drug development. A strong interest in applying the latest technological advances to better predict translation to patients.   Significant experience in the design and execution of studies to support project progression in the field of biologics drug discovery and development. Experience within the immunology, inflammation or oncology therapeutic areas. A proficiency with modalities such as multi-specifics or antibody drug conjugates (ADCs). Demonstrated proficiency in fostering and managing external collaborations with Contract Research Organizations (CROs) and world-leading academic groups. A