Senior Principal Software Engineer

Your Impact at LILA We are seeking a  Senior Principal Software Engineer  to join our software group and help build the next generation of our AI-driven scientific platform. In this role, as a technical leader, you will collaborate closely with ML researchers, platform engineers, and scientists to develop applications and services capable of supporting AI driven scientific process. You will also ensure seamless collaboration across diverse teams. You’ll have the opportunity to shape a modern, production-grade system from the ground up, working across a toolbox that includes cutting-edge AI frameworks, lab automation software, and scalable cloud infrastructure. In our fast-paced environment, your technical expertise and creative problem-solving will push the boundaries of what’s possible in AI-driven science. This is a unique chance to be at the forefront of applied AI in scientific research. If you are passionate about building intelligent systems that can transform science, we would love to hear from you! What You'll Be Building Lead End-to-End Software Development Lifecycle:  Drive the technical design, implementation, and maintenance of software systems and applications. Architect & Implement Applications : Design and build robust, scalable web applications and services across the full stack, empowering scientists to harness AI in their research workflows. Collaborate Cross-Functionally:  Partner with domain scientists, ML engineers, and product leads to integrate various technologies—ML models, data/compute infrastructure, and experimental automation tools. Establish Organizational Best Practices:  Set standards for code quality, testing, and documentation. Mentor junior engineers and foster a culture of knowledge sharing. Operationalize Code in Production: Leverage observability tooling to monitor real world performance and steer improvements. What You’ll Need to Succeed Bachelor’s or Master’s degree in Computer Science, Engineering, or a related field. 12+ years of experience successfully building and deploying scalable software systems in production environments. Technical Leadership:  Experience leading and mentoring a team and making key architecture decisions. 0→1 product development experience is required. Full Stack Development : Experience developing web apps across the full stack (React, TypeScript, Monorepos like Nx, TailWind, FastAPI, SQL/NoSQL, Python, Pydantic, Apache Iceberg, DuckDB) Cloud & DevOps Knowledge:  Hands-on experience with AWS, GCP, or Azure; strong understanding of Kubernetes, infrastructure-as-code (Terraform), and CI/CD pipelines (GitHub Actions). Communication & Collaboration : Leadership skills working cross functionally. Strong verbal and written communication. Acute listening skills, and a proven track record of working cross-functionally with scientists, data engineers, and product teams; able to explain complex ideas to diverse audiences. Bonus Points For Hands-On with Latest AI Tools:  Exposure to AI technologies such as LLMs or agentic frameworks, as well as experience leveraging AI to improve development performance. Experience with ORMs: Experience with and web services for CRUD services (SQLModel, FastAPI, Django). Orchestration Systems: Experience with orchestrators tools (Airflow, Prefect, Temporal, Flyte). Familiarity with Python for Science : Familiarity with data science and ML libraries (pandas, numpy, scipy, jax, pytorch). Domain Background:  Exposure to laboratory software or analytics for life sciences, material sciences, or related fields. Compensation We offer competitive compensation including bonus potential and generous early equity. The final offer will reflect your unique background, expertise, and impact. Expected Base Salary Range $232,000 — $390,000 USD About LILA Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves. LILA combines advanced AI models with proprietary AI Science Factory™ instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy. Learn more at www.lila.ai. Guided by our core values of truth, trust, curiosity, grit, and velocity, we move with startup speed while tackling problems of historic importance. If this sounds like an environment you'd love to work in, even if you don't meet every qualification listed above, we encourage you to apply. We’re All In Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Information you pro